Inflammatory neuropsychiatric disorders and COVID-19 neuroinflammation
نویسندگان
چکیده
Abstract Neuropsychiatric sequalae to coronavirus disease 2019 (COVID-19) infection are beginning emerge, like previous Spanish influenza and severe acute respiratory syndrome episodes. Streptococcal in paediatric patients causing obsessive compulsive disorder (PANDAS) is another recent example of an infection-based psychiatric disorder. Inflammation associated with neuropsychiatric disorders has been previously reported but there no standard clinical management approach established. Part the reason that it unclear what factors determine specific neuronal vulnerability efficacy anti-inflammatory treatment neuroinflammation. The emerging COVID-19 data suggested stage, widespread damage appears be result abnormal overactive immune responses cytokine storm poor prognosis. It still too early know if long-term-specific or brain regional damages COVID-19, resulting distinct disorders. In several major where neuroinflammation present, inflammatory markers may also experience less than favourable response resistance when used alone. Evidence regarding benefits co-administered agents such as COX-2 inhibitor encouraging selected though not benefit others. Disease-modifying therapies increasingly being applied diseases characterised by hyperreactive responses. Adjunct definitely important component presence
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ژورنال
عنوان ژورنال: Acta Neuropsychiatrica
سال: 2021
ISSN: ['1601-5215', '0924-2708']
DOI: https://doi.org/10.1017/neu.2021.13